Untitled Document
Not a member yet? Register for full benefits!

 Gap geometry grasped: A new algorithm could help understand the structure of liquids, and how they flow through porous media

This story is from the category Libraries and Components
Printer Friendly Version
Email to a Friend (currently Down)



Date posted: 07/02/2013

Theoretical physicist Moumita Maiti and colleagues at the Jawaharlal Nehru Centre for Advanced Scientific Research in Bangalore, India, have now implemented an algorithm for analysing void space in sphere packing, where the spheres need not all be the same size. This method, about to be published in EPJ E, could be applied to analyse the geometry of liquids present between multi-sized spheres that are akin to a model for porous material. This provides a tool for studying the flow of such fluids through porous material. More importantly, it can also be used to study the packing geometry of proteins.

There have been several previous attempts to calculate the volume and the surface area of packing of spheres. But few methods have taken into account the connectivity of empty space between spheres, which matters, for example, when detecting buried cavities in proteins.

To remedy this issue, the authors have relied on a programme capable of performing a very detailed study of the size distribution of the free volumes of individual spheres—that is, the volume swept by the centre of the sphere without overlapping with any of the other spheres—in jammed sphere packing. It also makes it possible to calculate the exact volumes and surface areas of cavities by detecting the disconnected components of cavities.

The team applied this method to the analysis of protein structures. This led them to compute various key quantities such as the distribution of sizes of buried cavities and pockets between spheres, the matching of areas accessible to solvent in which protein are found with the corresponding volumes and the composition of residues lining cavities.

Ultimately, the authors are planning to prepare this algorithm for distribution as open source software.

See the full Story via external site: www.springer.com

Most recent stories in this category (Libraries and Components):

17/02/2015: New algorithms Geolocate a video from its images and sounds

25/03/2014: Parallel programming may not be so daunting

24/01/2014: Stanford scientists use 'virtual earthquakes' to forecast Los Angeles quake risk

14/04/2013: The mathematical method for simulating the evolution of the solar system has been improved by UPV/EHU researchers

13/02/2013: 3D Printing on the Micrometer Scale

07/02/2013: Gap geometry grasped: A new algorithm could help understand the structure of liquids, and how they flow through porous media

03/12/2012: The advantages of 3D printing are now being put to the test in soil science laboratories

02/12/2012: Preventing 'Cyber Pearl Harbor'